Flow Cytometry US Group Leader

Site Name: USA - Pennsylvania - Upper Providence

Posted Date: Apr 30 2024

This role will be located in Collegeville, PA and will require the new employee to work 5 days a week onsite to support our employees working in the Laboratory.

We are looking for a highly motivated, agile and experienced immunologist to lead our Cellular Biomarkers Flow Cytometry team within the Biomarker and Bioanalytical Platforms department. Our group is responsible for developing and validating complex multi-parameter biomarker assays for use in clinical studies. We generate deep immunophenotyping data to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.

The successful Director, Flow Cytometry US Group Leader will have a deep understanding of immunology and will serve both as a group leader and as a technical expert.

Key Responsibilities

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:

• Provide scientific leadership and guide the development and validation of various high parameter spectral (Cytek Aurora) flow cytometry assays including deep immunophenotyping of immune cell subsets and receptor occupancy endpoints.
• Oversee all aspects of method development, troubleshooting, validation and sample analysis for those clinical studies withflow cytometry endpoints.
• Manage, develop and train a team of PhD and non-PhD scientists
• Provide biomarker/translational expertise on multiple clinical programs/projects including influencing biomarker strategy
• Be responsible for delivery of robust, high-quality data packages
• Ensure all work is conducted in compliance with GCLP regulations and follow the appropriate SOPs.
• Guide your team in successful interactions with CRO partners to assist in the delivery of high-quality clinical flow cytometry endpoints
• Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines
• Ability to handle multiple projects concurrently
• Able to function well in a team and possess a good balance of creative and analytical skills
• Contribute to capital equipment discussion
• Lead efforts to investigate novel flow cytometry data analysis platforms and embed them within the organization

Why You?

Minimum Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in immunology, cell biology or similar field
• 6 or more years post-PhD work experience in immunology, cell biology, or biomedical science
• Experience in biomarker/translational work on multiple clinical programs/projects
• People leadership experience of a large team ( 10 to 15 direct reports) and ability to lead a team of PhD and non-PhD level scientists
• Experience in immunology covering phenotyping of multiple lineages of cells
• Laboratory experience working with clinical and non-clinical flow cytometry biomarker assay development, validation, and implementation
• Experience in high dimension flow cytometry and in the design and execution 16+ color flow cytometry panels
• Experience in the use of flow cytometry analysis software like OMIQ
• Experience working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspension from tissue samples

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Excellent collaboration and interpersonal skills to influence biomarker testing strategies and communicate efficiently with colleagues from all phases of clinical drug development
• Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence
• Ability to problem solve and troubleshoot
• Demonstrated judgment and decision making, especially for prioritizing multiple requests
• Experience in the development and validation of novel flow cytometry assays to support clinical measurements and their translation to a companion diagnostic (CDx) when applicable.
• Experience of working with external vendors for the transfer of assays to support clinical trial sample analysis and development of CDx (where appropriate)
• Experience to design and execute 25+ color flow cytometry panels
• Hands on experience with the Cytek Aurora
• Hands on experience with OMIQ
• Proactively demonstrate the ability to work to tight deadlines

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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